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A gradual reduction in the dose rather than abrupt cessation is recommended whenever possible. Le lisinopril administré à la dose de 10 à 20 mg/jour pendant 12 mois a permis une réduction de la pression artérielle systolique et diastolique de respectivement 13 mmHg et 10 mmHg et une diminution de l'albuminurie de 40 %Par rapport au groupe traité par antagoniste calcique, duphaston une réduction significativement plus importante de l'albuminurie a été observée sous lisinopril, alors que la diminution de la pression artérielle a été similaire dans les 2 groupes.

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